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Neo Owners :: Forums :: Health and Nutrition :: Endocrine		<< Previous thread \| Next thread >>
Von Willebrand's Disease


Moderators: maximus, jessica, All about Eva, Igmuska

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All about Eva

Fri Dec 19 2008, 12:30PM

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I have seen multiple post on different websites about von willebrants in neos. My vet is suspicious of this in my dog. This was before she even knew that it is known in neos. After talking this over with my breeder ( who I love by the way) She is convinced that it is not something neos can have. I am going to have her tested in the next few weeks no matter what. But my breeder says she has never heard of this and has never heard of this in neos. Has anyone actually heard of or seen a neo with Von Willebrants before?

[ Edited Wed Dec 24 2008, 10:31AM ]

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jessica (20 Dec : 09:03)

BluHouse

Fri Dec 19 2008, 02:09PM

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There are many different elements involved with clotting, the 2 page+ pathway I learned just a couple of years ago has already been extended and revised and any problems at any point along this pathway can lead to excessive bleeding (vWD, hemophelia etc.) Could a Neo have vWD? Absolutely. I haven't heard of one but I know the bull mastiff and OEM people are starting to test for it. Get a complete clotting profile done on your dog and go from there. Just because there is no known documented case of vWD in the Neo does not mean the disease does not exist.
Robin

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jessica (20 Dec : 09:03)

All about Eva

Sun Dec 21 2008, 08:25PM

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After about a month after receiving my little girl, she started urinating straight blood!! 2 free catch u/a's showed not signs of infection. The culture came back neg. also. My vet beleived it could be von willebrants. We did one course of antibiotics with no change in urine at all!! Then we did a stronger course for a week and it seem to clear up. It was stated if she had another bought of it we need to do the test. What was odd was, she has had all her shots not one problem and also had cherry eye surgery also with no problems. ( the cherry eye surgery was done while she was still having urine issues.) Both went great with no problems or reactions you would see with Von Willebrants. I will be running the VW test in January just for peice of mind, but it all seems so odd to me. The only other issue I could see playing a role is diet switch. This started after I had switched her from the breeders food to another food. I know this can cause PH changes but that drastic!!? We will be switching her food again but I am so hesitant this will happen again. Any thoughts. I work in Vet Medicine and will do any thing that is needed. Xray came back neg for stones. (some are not visible on xray) and no crystal on u/a either. Complete blood profile was with in normal limits also. I do not go back to work until January 10 and that is when we will do the VW test and another complete blood panel. Has anyone seen or heard of anything like this? I am so confused and worried. Thanks for listening, any advise would be GREATLY appreciated.

jessica

Mon Dec 22 2008, 10:06AM

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Boy Sara...I am So sorry...I wish I could say that I have seen or heard of this. But I have not.....Please keep us up to date with all findings..And take care

jessica

Tue Dec 23 2008, 09:04AM

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Here is Some info I found on this subject.

What Is von Willebrand Disease?
Von Willebrand disease (VWD) is an inherited bleeding disorder. It affects your blood's ability to clot. If your blood doesn't clot, you can have heavy, hard-to-stop bleeding after an injury. The bleeding can damage your internal organs or even be life threatening, although this is rare.

In VWD, you either have low levels of a certain protein in your blood, or the protein doesn't work the way it should. The protein is called von Willebrand factor, and it helps the blood clot.

Normally, when one of your blood vessels is injured, you start to bleed. Small blood cells called platelets (PLATE-lets) clump together to plug the hole in the blood vessel and stop the bleeding. Von Willebrand factor acts like glue to help the platelets stick together and form a blood clot.

Von Willebrand factor also carries clotting factor VIII (8), another important protein that helps your blood clot. Factor VIII is the protein that's inactive or missing in hemophilia, another clotting disorder.

VWD is more common and usually milder than hemophilia. In fact, VWD is the most common of all the inherited bleeding disorders. It occurs in about 1 out of every 100 to 1,000 people. VWD affects both males and females, while hemophilia mainly affects males.

Types of von Willebrand Disease
There are three major types of VWD.

Type 1
In type 1 VWD, you have a low level of the von Willebrand factor, and you may have lower levels of factor VIII than normal. This is the mildest and most common form of the disease. About 3 out of 4 people who have VWD have type 1.

Type 2
In type 2 VWD, the von Willebrand factor doesn’t work the way it's supposed to. Type 2 is divided into subtypes: 2A, 2B, 2M, and 2N. Different gene mutations cause each type, and each is treated differently. This makes knowing the exact type of VWD that you have very important.

Type 3
In type 3 VWD, you usually have no von Willebrand factor and low levels of
factor VIII. Type 3 is the most serious form of VWD, but it’s very rare.

Overview
Most people with VWD have type 1, a mild form. This type usually doesn't cause life-threatening bleeding, and you may need treatment only if you have surgery, tooth extraction, or trauma. If you need treatment, medicines and medical therapies are used.

Some people with severe forms of VWD need to seek emergency treatment to stop bleeding before it becomes life threatening.

Early diagnosis is important. With the right treatment plan, even people with type 3 VWD can be helped to live normal, active lives.

jessica

Tue Dec 23 2008, 09:20AM

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Heres a link for info with vWD/dogs

-link-

All about Eva

Tue Dec 23 2008, 11:03AM

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Location: missouri
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Thank you very much for the info! I have been driving my self crazy and can not wait to just finally get the test done and overwith!!!!! January 10 seems soooooooooooo far away.

Neolady

Wed Dec 24 2008, 09:54AM

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I had 2 of mine tested so far. Akilies being a 117 and Athena being a 135. Carriers are between 0-49 Borderline would between 50 -59 and normal being between 70-180.I plan on tested the others next year.

1 User said Thank to Neolady for this Post :
jessica (24 Dec : 10:09)


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